Powered by Bioz3 TYPES OF FIBER (CELLULOSIC, POLYSULFONE, PVDF)
Cat # C2025
0.1 µm pore size for the highest exchange rates but without protein retention. 80 cm2 outer surface area. PVDF fiber allow for the attachment of matrix proteins, cytokines and antibodies. Ideal fiber for endothelial cell culture under sheer.
Cat # C2025D
20 kD MWCO polysulfone fiber with 450 cm2 of surface area. Only one wrap of oxygenation tubing to reduce system dead volume.
Cat # C2008
Low MWCO (5 kD @ 50%) hydrophilic polysulfone fiber for recombinant proteins between 25 kD and 100 kD. Appropriate for adherent and suspension cell lines including CHO, HeLa and 293. Can support up to 109 cells and produce 100 µg/mL/day or more of recombinant protein in 20 mL ECS.
Cat # C2011
High MWCO (20 kD @ 50%) hydrophilic polysulfone fiber for monoclonal antibodies and larger recombinant proteins (100 kD or larger). Can support up to 109 cells and produce 1-5 mg of a recombinant protein every day or 5-100 mg of a monoclonal antibody every other day. This is the cartridge of choice for PK/PD studies.
Cat # C5011
The C5011 is the same cartridge as the C2011 but with twice the oxygenation capacity. It is specifically designed for hybridoma scale-up with 2X greater productivity and twice the antibody concentration of the C2011.
Cat # C8008
Cellulosic cartridge with 12.5 kD MWCO. Cellulosic fibers are solvent resistant and may offer lower non-specific binding to non-polar drugs than the polysulfone fiber.
Cat # C2003
Low MWCO (5 kD @ 50%) hydrophilic polysulfone fiber for recombinant proteins between 25 kD – 100 kD. 1.2 m2 of surface area will support up to 5X1010 cells and produce 5-20 mg of recombinant protein every day in an ECS volume of 60 mL.
Cat # C2018
High MWCO (20 kD @ 50%) hydrophilic polysulfone fiber for larger recombinant proteins (100 kD or larger). Can support up to 5X 1010 cells and produce 5-20 mg of protein every day in a volume of 60 mL. Appropriate for adherent or suspension cell lines including CHO, HeLa, BHK and 293 cells.
Cartridge/Flowpath Specifications
| Catalog No. | Size | Surface Area |
Fiber Type | Packing Density |
ECS Vol | MWCO 50% |
Max. Cell# | Oxygenator |
| C2025 | Small | 80 cm2 | PVDF | 39% | 3.9 mL | 0.1 µm | 108 | 1.5 m |
| C2025D | Small | 450 cm2 | High flux PS | 50% | 3.2 mL | 20 kD | 108 | .65 m |
| C2025F | Small | 450 cm2 | Low flux PS | 50% | 3.2 mL | 5 kD | 108 | .65 m |
| C2008 | Medium | 4000 cm2 | Low flux PS | 50% | 20 mL | 5 kD | 109 | 4 m |
| C2011 | Medium | 4000 cm2 | High flux PS | 50% | 20 mL | 20 kD | 109 | 4 m |
| C5011 | Medium | 4000 cm2 | High flux PS | 50% | 20 mL | 20 kD | 2 x 109 | 6.1 m |
| C7011 | Medium | 880 cm2 | Hydrophilic PVDF | 50% | 24mL | .03 µm | NA | .65 m |
| C8008 | Medium | 1620 cm2 | Cellulosic | 38% | 32 mL | 12.5kD | NA | .65 m |
| C2003 | Large | 1.2 m2 | Low flux PS | 50% | 70 mL | 5 kD | 5 x 1010 | 6.1 m |
| C2018 | Large | 1.2 m2 | High flux PS | 50% | 70 mL | 20 kD | 5 x 1010 | 6.1 m |
Unsure of which cartridge is best for your application?
Many other cell types have been cultured in the FiberCell Systems hollow fiber bioreactor system. FiberCell Systems can provide the benefits of a combined 20 years plus experience with working with these systems and would be happy to discuss your application. Contact us now for a free consultation.
The FiberCell Systems cartridge shown with tubing
FiberCell Systems cartridges are supplied assembled with the flow path ready to use. They are pre-sterilized and double bagged with instructions provided.
Click here for our US list pricing for 2023. We offer tiered discounted pricing for quantity purchases of our products, 10-25 units, 25+ units, and 50+ units. Please enquire for details. We recommend the most appropriate products for your applications so please feel free to email or phone us to discuss your application and provide you with a quote at info@fibercellsystems.com, 301-471-1269, 240-440-2662. We can accept credit cards and purchase orders from accredited institutions.
