In Vitro Toxicology

Hollow fiber cartridge systems from FiberCell™ Systems have been used to model pharmacologic bio-availability for different antimicrobial drugs and also to mimic dosage profiles that generate resistant organisms. Anti-cancer agents, anti-fungals, antibiotics, anti-virals (including anti-HIV) and anti-parasitic drugs have all been tested in the hollow fiber system.

This system mimics in vivo drug dosage profiles in a rigorously controlled in vitro system composed of a hollow fiber cartridge and associated pumps and reservoirs. Bio-availability can be controlled in a precise fashion and any dosage profile can be evaluated.

Advantages of the hollow fiber system:

  1. Large number of bacteria can be supported
  2. Bio-hazardous organisms can be handled safely
  3. Concentration of the drug can be precisely controlled
  4. Disposable system

Above: Dr. James McSharry from Ordway Research Institute with John Cadwell of FiberCell Systems

The high gross filtration rate of the FiberCell™ Systems cartridges results in rapid equilibration of drugs across the fiber and the even distribution of the fiber bundle inside the cartridge shell makes the system ideal even for suspension organisms.

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SUGGESTED ORDERING FOR IN VITRO TOXICOLOGY:

BIOREACTOR
P3202
The FiberCell Systems Duet more info
CARTRIDGES
Stock No.
Size
Surface Area
Fiber Type
Packing Density
ECS Vol
MWCO 50%
Max. Cell#
  
C2011
Medium
3000cm2
high flux PS
50%
15mL
20kd
109
more info
C3008
Medium
2000cm2
Cellulosic
38%
12mL
10kd
1011
 more info
RESERVOIR CAPS
A1006
38mm Reservoir Cap more info