Hollow fiber cartridge systems from FiberCell^® Systems have been used to model pharmacologic bio-availability for different antimicrobial drugs and also to mimic dosage profiles that generate resistant organisms. Anti-cancer agents, anti-fungals, antibiotics, anti-virals (including anti-HIV) and anti-parasitic drugs have all been tested in the hollow fiber system.

This system mimics in vivo drug dosage profiles in a rigorously controlled in vitro system composed of a hollow fiber cartridge and associated pumps and reservoirs. Bio-availability can be controlled in a precise fashion and any dosage profile can be evaluated.

Advantages of the hollow fiber system:

1. Large number of bacteria can be supported
2. Bio-hazardous organisms can be handled safely
3. Concentration of the drug can be precisely controlled
4. Disposable system