The FiberCell^® PS+ module (cat#4300-C2025) is especially designed for the culture and study of endothelial cells under flow. The PS+ fiber can easily be coated with extra-cellular matrix proteins (and/or cytokines and antibodies) to permit the attachment of endothelial cells to the interior wall of the fiber. The microprocessor controlled FiberCell^® Systems pump can be programmed to produce consistent and defined amounts of shear stress by regulating the flow of medium over the cells. This allows the study of endothelial cells in a more physiologic environment when compared to other methods. As a result, typical cell morphology is retained, a monolayer is formed and tight junctions are created. These culture conditions more closely mimic in vivo cell growth.The microporous nature of the fibers and the ability to control the extra-cellular matrix provides an ideal system for cellular co-cultivation with other cell types such as vascular smooth muscle or neuroglia.

(Figure above right: Human coronary endothelial cells. Curtesy of Guerkan Sengoelge, Medical University of Vienna)