In Vitro Toxicology
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Hollow fiber cartridge systems from FiberCell™ Systems have been used to model pharmacologic bio-availability for different antimicrobial drugs and also to mimic dosage profiles that generate resistant organisms. Anti-cancer agents, anti-fungals, antibiotics, anti-virals (including anti-HIV) and anti-parasitic drugs have all been tested in the hollow fiber system.

This system mimics in vivo drug dosage profiles in a rigorously controlled in vitro system composed of a hollow fiber cartridge and associated pumps and reservoirs. Bio-availability can be controlled in a precise fashion and any dosage profile can be evaluated.

Advantages of the hollow fiber system:

1) Large number of bacteria can be supported.
2) Bio-hazardous organisms can be handled safely
3) Concentration of the drug can be precisely controlled
4) Disposable system

The high gross filtration rate of the FiberCell™ Systems cartridges results in rapid equilibration of drugs across the fiber and the even distribution of the fiber bundle inside the cartridge shell makes the system ideal even for suspension organisms.


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